ESP 55016
ETC-1002
CAS: 738606-46-7
Molecular Formula: C19H36O5
ESP 55016 - Names and Identifiers
| Name | ETC-1002 |
| Synonyms | CS-1544 ETC-1002 ESP 55016 Bempedoate Bempedoic Acid ETC-1002 (ESP 55016) Bempedoic Acid(ETC-1002 ETC-1002(BEMPEDOIC ACID) |
| CAS | 738606-46-7 |
ESP 55016 - Physico-chemical Properties
| Molecular Formula | C19H36O5 |
| Molar Mass | 344.49 |
| Density | 1.045±0.06 g/cm3(Predicted) |
| Melting Point | 87 - 92°C |
| Boling Point | 506.5±35.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 4.55±0.45(Predicted) |
| Storage Condition | Refrigerator |
| In vitro study | ETC-1002 is a novel and under investigation LDL-C-lowering small molecule. It is a dicarboxylic acid faction. Its mechanism of action is mainly to target two liver enzymes: adenosine triphosphate-citrate lyase (ACL) and adenosine monophosphate-activated protein kinase (AMPK) inhibit sterol and fatty acid synthesis and promote mitochondrial long-chain fatty acid oxidation. ETC-1002 increases AMPK phosphorylation levels, decreases MAPKs activity, and decreases pro-inflammatory cytokine and chemokine production. These ETC-1002 effects of regulating soluble inflammatory factors can be significantly inhibited by LKB1 siRNAs, suggesting that ETC-1002 may activate AMPK and exert its anti-inflammatory effect through lkb1-dependent mechanisms. |
| In vivo study | In vivo experiments, ETC-1002 inhibited the migration of sulfur glia-induced leukocytes to the peritoneal cavity of mice. Similarly, in a mouse model of diet-induced obesity, ETC-1002 restored adipose AMPK activity, decreased JNK phosphorylation, and reduced macrophage-specific marker 4F/80 expression. ETC-1002 is a pro-drug in an inactive state that is converted in vivo by endogenous liver ACS activity into an ACL inhibitor (active state, ECT-1002-CoA). |
ESP 55016 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.903 ml | 14.514 ml | 29.029 ml |
| 5 mM | 0.581 ml | 2.903 ml | 5.806 ml |
| 10 mM | 0.29 ml | 1.451 ml | 2.903 ml |
| 5 mM | 0.058 ml | 0.29 ml | 0.581 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: Bempedoic Acid（ETC-1002） Visit Supplier Webpage Request for quotationCAS: 738606-46-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: ETC-1002 Visit Supplier Webpage Request for quotation
CAS: 738606-46-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 738606-46-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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